Tamsulosin
helps men with BPH
Tamsulosin
Tamsulosin Indications Contraindications Cautions Dosing Drug interactions Side effects
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Tamsulosin | National Library of Medicine

Tamsulosin

tamsulosin capsule

Tamsulosin is selective and competitive antagonist of postsynaptic α1A-adrenergic receptors. Tamsulosin reduces smooth muscle tone in the prostate and urethra. It increases the maximum urinary flow rate, relieve the symptoms and stagnation. Reduction of symptoms associated with filling and emptying of the bladder is maintained during long-term therapy. The drug is rapidly absorbed from the gastrointestinal tract, bioavailability is almost complete, reduces the absorption of food. After a single dose maximum plasma concentration occurs after about 6 h Steady state is achieved after approximately 5 days of taking the drug. Tamsulosin binds to plasma proteins is approximately 99%. Is metabolised in the liver and excreted primarily in the urine, 9% of the dose - unchanged. T0, 5 in the adoption of the single product after the meal is about 10 h in the steady state of approximately 13 hr

Indications

The symptoms related to lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia.

1 capsule contains sustained release of tamsulosin hydrochloride 0.4 mg. The product contains sucrose, sunset yellow and azorubine.

The drug is intended for use in men.

Contraindications

Hypersensitivity to tamsulosin hydrochloride or any of the excipients, including angioedema caused by the drug. Orthostatic hypotension in an interview. Severe hepatic impairment.

Cautions

Due to the lack of clinical trials used with caution in patients with severe renal impairment (creatinine clearance <10 mL / min). Use caution in patients with significant hepatic impairment. It is not recommended to initiate treatment with tamsulosin in patients for whom surgical treatment is planned cataract surgery (risk of intraoperative Floppy Iris team - IFIS - during cataract surgery). The product contains sucrose - it should not be administered to patients with rare hereditary problems of fructose intolerance, malabsorption glucose-galactose malabsorption or sucrase-isomaltase. Included in the preparation sunset yellow and azorubine may cause allergic reactions.

Side effects

Common: dizziness, abnormal ejaculation. Uncommon: headache, palpitations, orthostatic hypotension, rhinitis, constipation, diarrhea, nausea, vomiting, rash, pruritus, urticaria, asthenia. Rare: syncope, angioedema. Very rare: Stevens-Johnson syndrome, priapism.

Dosing

Oral. Adults: 1 capsule a day, after breakfast or the first meal of the day. The capsules should be swallowed whole.

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